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Ischemic heart disease fatalities increased considerably in two Canadian studies, despite PM 2.5 being less than 9 g per cubic meter on average (87, 89)

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Measuring the concentration of nicotine in a sample of tobacco smoke in the particulate phase ( c p,t ) allows calculation of the fraction of unprotonated nicotine: fb = c p,u / c p,t (Pankow et al